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KMID : 1009020230210020386
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Clinical Psychopharmacology and Neuroscience
2023 Volume.21 No. 2 p.386 ~ p.390
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Possible Link between Serotonin and Interleukin 18 on Suicidality in Patients with Acute Coronary Syndrome
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Kim Jae-Min
Kang Hee-Ju
Kim Ju-Wan
Choi Won-Suk
Kim Sung-Wan
Shin Ji-Hoon
Chun Byung-Jo
Ahn Young-Keun
Jeong Myung-Ho
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Abstract
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Objective: We investigated effects of serum serotonin and interleukin 18 levels on suicidal ideation (SI) at acute and chronic phases of acute coronary syndrome (ACS).
Methods: Recent-onset 969 ACS patients were evaluated for serum serotonin and interleukin 18 levels; and SI by the “suicidal thoughts” item of the Montgomery?Asberg Depression Rating Scale. After 1-year, 711 patients were re-evaluated for SI. Logistic regression models were used adjustment for potential covariates.
Results: Associations between serum interleukin 18 and SI at both phases were significant only in the lower serotonin group.
Conclusion: By evaluating serum serotonin and interleukin 18 levels, the clinical prediction of SI of ACS may be improved.
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KEYWORD
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Serotonin, Interleukin 18, longitudinal study, Suicidal ideation, Acute coronary syndrome
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